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(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

Moexipril hydrochloride

CAS: 82586-52-5

Molecular Formula: C27H35ClN2O7

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  5. (3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride - Names and Identifiers

Name Moexipril hydrochloride
Synonyms UNIVASC
RS10085
RS 10085
RS-10085
Moexipril HCl
Moexipril hydrochloride
(3S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl}-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, hydrochloride
(3S)-2-[(2S)-2-{[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisochinolin-3-carbons?urehydrochlorid
2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylicacidhydrochloride
(3S)-2-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-Phenyl-Propyl]Amino]Propanoyl]-6,7-Dimethoxy-3,4-Dihydro-1H-Isoquinoline-3-Carboxylic Acid Hydrochloride
(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid hydrochloride
(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
acide (3S)-2-[(2S)-2-{[(1S)-1-(éthoxycarbonyl)-3-phénylpropyl]amino}propanoyl]-6,7-diméthoxy-1,2,3,4-tétrahydroisoquinoléine-3-carboxylique chlorhydrate
3-isoquinolinecarboxylic acid, 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, (3S)-, monohydrochloride
(3S-(2(R*(R*)),3R*))-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-3-isoquinolinecarboxylic acid monohydrochloride
CAS 82586-52-5
EINECS 617-363-1
InChI InChI=1/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1

(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride - Physico-chemical Properties

Molecular FormulaC27H35ClN2O7
Molar Mass535.03
Melting Point141-1610C
Boling Point709.3°C at 760 mmHg
Specific Rotation(α)D23 +34.2° (c = 1.1 in ethanol)
Flash Point382.8°C
Solubility DMSO 20 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Vapor Presure4.1E-21mmHg at 25°C
Appearancepowder
Storage Condition2-8°C
MDLMFCD00940481
UseMoexipril HCl is a potent orally active non sulfhydryl angiotensin converting enzyme(ACE) inhibitor
In vitro studyMoexipril dose-dependently reduced the percentage of injured neurons, as well as glutamate, staurosporine, or ferric ion-induced mitochondrial reactive oxygen species production. Moexipril and Enalapril attenuated staurosporine-induced neuronal apoptosis, as determined by nuclear staining of hoechst33258.
In vivo studyAs compared to control mice, Moexipril(0.3 mg/kg) significantly reduced brain injury after focal ischemia. In a rat model of cerebral ischemia, Moexipril(0.01 mg/kg) reduced infarct volume. In the tibia of ovariectomized (OVX) spontaneously hypertensive rats (SHR), Moexipril lowers blood pressure. The combination of Moexipril and hydrochrothiazide (HCTZ) showed a more powerful blood pressure lowering effect, with the same effect on bone mass and dynamic endpoints. In rabbit lung, Moexiprilat showed a greater inhibitory effect on plasma ACE and purified ACE than enalaprilat. Moexipril(0.1-30 mg/kg/day) lowered blood pressure and inhibited ACE activity in plasma, lung, aorta, heart, and kidney in a dose-dependent manner. Moexipril(10 mg/kg/day) caused a decrease in blood pressure, inhibited plasma ACE and reduced plasma angiotensinogen, attenuated the pressure response of angiotensin I and the hypotensive response of bradykinin.

(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride - Risk and Safety

Hazard SymbolsN - Dangerous for the environment
Dangerous for the environment
Risk Codes50 - Very Toxic to aquatic organisms
Safety Description60 - This material and its container must be disposed of as hazardous waste.
UN IDsUN 3077 9/PG 3
WGK Germany3
RTECSNW7174500
HS Code2933492250

(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride - Introduction

Moexipril HCl is an orally effective non-thiol angiotensin converting enzyme (ACE) inhibitor with an IC50 of 0.041 μM for the treatment of hypertension and congestive heart failure.
Last Update：2022-10-16 17:29:10

(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride - Reference Information

biological activity moexibril HCl (RS-10085) is an orally effective non-thiol angiotensin converting enzyme (ACE) inhibitor, the IC50 is 0.041 µm and is indicated for the treatment of hypertension and congestive heart failure.
TargetValue
ACE
Last Update：2024-04-09 21:00:56
(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
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CAS: 82586-52-5
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Moexipril HCl Visit Supplier Webpage Request for quotation
CAS: 82586-52-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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(3S)-2-[(2S)-2-{[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propanoyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
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